Check Credit Score
Check Credit Score
HomeNewsWorld

9 reasons you can be optimistic that a vaccine for COVID-19 will be widely available in 2021

Here is where the current research stands and why you can be optimistic about the delivery of a COVID-19 vaccine.

August 25, 2020 / 03:55 PM IST
Representative image

Representative image

As fall approaches rapidly, many are wondering if the race for a vaccine will bear fruit as early as January 2021.

I am a physician-scientist and infectious diseases specialist at the University of Virginia, where I care for patients and conduct research into COVID-19. I am occasionally asked how I can be sure that researchers will develop a successful vaccine to prevent COVID-19. After all, we still don’t have one for HIV, the virus that causes AIDS.


Here is where the current research stands, where I think we will be in five months and why you can be optimistic about the delivery of a COVID-19 vaccine.

1. Human immune system cures COVID-19


In as many as 99 percent of all COVID-19 cases, the patient recovers from the infection, and the virus is cleared from the body.

Some of those who have had COVID-19 may have low levels of virus in the body for up to three months after infection. But in most cases these individuals can no longer transmit the virus to other people 10 days after first becoming sick.


It should therefore be much easier to make a vaccine for the new coronavirus than for infections such as HIV where the immune system fails to cure it naturally. SARS-CoV-2 doesn’t mutate the way that HIV does, making it a much easier target for the immune system to subdue or for a vaccine to control.

2. Antibodies targeting spike protein prevent infection


A vaccine will protect, in part, by inducing the production of antibodies against the spike protein on the surface of SARS-CoV-2, the virus that causes COVID-19.

COVID-19 Vaccine

Frequently Asked Questions

View more
How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

View more
Show

The virus needs the spike protein to attach to and enter human cells to reproduce. Researchers have shown that antibodies, like those made by the human immune system, bind to the spike protein, neutralize it and prevent the coronavirus from infecting cells in laboratory culture.

Vaccines in clinical trials have been shown to raise anti-spike antibodies that block virus infection in cells in the lab.

At least seven companies have developed monoclonal antibodies, laboratory-manufactured antibodies that recognize the spike protein. These antibodies are entering clinical trials to test their ability to prevent infection in those who are exposed, for example, through a household contact.


Monoclonal antibodies may also be effective for treatment. During an infection, a dose of these monoclonal antibodies could neutralize virus, giving the immune system a chance to catch up and manufacture its own antibodies to combat the pathogen.

3. Spike glycoprotein contains multiple targets


The spike protein has many locations where antibodies can bind to and neutralize the virus. That’s good news because with so many vulnerable spots, it will be difficult for the virus to mutate to avoid a vaccine.


Multiple parts of the spike would need to mutate to evade neutralizing anti-spike antibodies. Too many mutations to the spike protein would change its structure and render it incapable of binding to ACE2, which is key to infecting human cells.

4. We know how to make a safe vaccine


Safety of a new COVID-19 vaccine is improved by researchers’ understanding of potential vaccine side effects and how to avoid them.

One side effect seen in the past was antibody-dependent enhancement of infection. This occurs when antibodies don’t neutralize the virus but instead allow it to enter into cells via a receptor intended for antibodies. Researchers have found that by immunizing with the spike protein, high levels of neutralizing antibodies can be produced. This lessens the risk of enhancement.


A second potential problem posed by some vaccines is an allergic reaction that causes inflammation in the lung, as was seen in individuals who received a respiratory syncytial virus vaccine in the 1960s. This is dangerous because inflammation in the lung air spaces can make it difficult to breathe. However, researchers have now learned how to design vaccines to avoid this allergic response.

5. Several different vaccines in development


The US government is supporting the development of several different vaccines via Operation Warp Speed.

The goal of Operation Warp Speed is to deliver 300 million doses of a safe and effective vaccine by January 2021.

The US government is making a major investment, committing US$8 billion to seven different COVID-19 vaccines.


By supporting multiple COVID-19 vaccines, the government is hedging its bets. Only one of these vaccines needs to prove safe and effective in clinical trials for a COVID-19 vaccine to be made available to Americans in 2021.

6. Vaccines passing through phase I and II trials


Phase I and phase II trials test if a vaccine is safe and induces an immune response. Already the results to date from three different vaccine trials are promising, triggering the production of anti-spike neutralizing antibodies levels that are two- to four-fold higher than those seen in people who have recovered from COVID-19.


ModernaOxford and Chinese company CanSino have all demonstrated the safety of their vaccines in phase I and phase II trials.

7. Phase III clinical trials are underway


During a phase III trial, the final step in vaccine development process, the vaccine is tested on tens of thousands of individuals to determine if it works to prevent infection with SARS-CoV-2, and that it is safe.


The vaccine produced by Moderna and NIH and the vaccine from Oxford-AstraZeneca began phase III trials in July. Other COVID-19 vaccines will be starting phase III within weeks.

8. Accelerating vaccine production and deployment


Operation Warp Speed is paying for the production of millions of doses of vaccines and supporting vaccine manufacturing at an industrial scale even before researchers have demonstrated vaccine efficacy and safety.

The advantage of this strategy is that once a vaccine is proven safe in phase III trials, a stockpile of it will already exist and it can be distributed immediately without compromising full assessment of safety and efficacy.


This is a more prudent approach than that of Russia, which is vaccinating the public with a vaccine before it has been shown to be safe and effective in phase III.

9. Vaccine distributors are being contracted now


McKesson Corp., the largest vaccine distributor in the US, has already been contracted by the CDC to distribute a COVID-19 vaccine to sites – including clinics and hospitals – where the vaccine will be administered.

I believe that it is realistic that we will know sometime in late 2020 whether some COVID-19 vaccines are safe, exactly how effective they are and which ones should be used to vaccinate the US population in 2021.

Follow our full coverage of the coronavirus pandemic here.

AP News
first published: Aug 25, 2020 03:54 pm

Discover the latest business news, Sensex, and Nifty updates. Obtain Personal Finance insights, tax queries, and expert opinions on Moneycontrol or download the Moneycontrol App to stay updated!

Advisory Alert: It has come to our attention that certain individuals are representing themselves as affiliates of Moneycontrol and soliciting funds on the false promise of assured returns on their investments. We wish to reiterate that Moneycontrol does not solicit funds from investors and neither does it promise any assured returns. In case you are approached by anyone making such claims, please write to us at grievanceofficer@nw18.com or call on 02268882347